Bacterial Chromatin

William Margolin Abstract This chapter outlines how important properties of the bacterial nucleoid have been discovered by direct visualization of the nucleoid in situ by microscopy. Relatively new tools for these investigations include ...

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Author: Remus T. Dame

Publisher: Springer Science & Business Media

ISBN: 9789048134731

Category: Science

Page: 450

View: 540

The birth and the development of molecular biology and, subsequently, of genetic engineering and biotechnology cannot be separated from the advancements in our knowledge of the genetics, biochemistry and physiology of bacteria and bacter- phages. Also most of the tools employed nowadays by biotechnologists are of bacterial (or bacteriophage) origin and the playground for most of the DNA manipulations still remains within bacteria. The relative simplicity of the bacterial cell, the short gene- tion times, the well defined and inexpensive culturing conditions which characterize bacteria and the auto-catalytic process whereby a wealth of in-depth information has been accumulated throughout the years have significantly contributed to generate a large number of knowledge-based, reliable and exploitable biological systems. The subtle relationships between phages and their hosts have produced a large amount of information and allowed the identification and characterization of a number of components which play essential roles in fundamental biological p- cesses such as DNA duplication, recombination, transcription and translation. For instance, to remain within the topic of this book, two important players in the or- nization of the nucleoid, FIS and IHF, have been discovered in this way. Indeed, it is difficult to find a single fundamental biological process whose structural and functional aspects are better known than in bacteria.

Bacterial Chromatin

Most of these papers, spanning the fields of physical chemistry through biochemistry to genetics, were presented at the session on bacterial chromatin during the Symposium “Selected topics on chromatin structure and function” held at ...

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Author: Claudio O. Gualerzi

Publisher: Springer Science & Business Media

ISBN: 9783642712661

Category: Science

Page: 227

View: 739

This book brings together various contributions aimed at the elucida tion of the structural and functional organization of the bacterial nucleoid. Most of these papers, spanning the fields of physical chemistry through biochemistry to genetics, were presented at the session on bac terial chromatin during the Symposium "Selected topics on chromatin structure and function" held at the University of Camerino, Italy, at the end of May 1985. Times when the bacterial DNA was regarded as "naked" or, at most, complexed with polyamines, and when the absence of histones and organized chromatin was considered to be a distinct feature of the pro karyotic cell, now appear remote. Our concepts of how DNA is packaged in bacteria are changing rapidly. Studies on the structure of the bacterial nucleoid are not new. Recently, however, investigations in this field have flourished again, leading to some important contributions such as the elucidation of the three-dimensional structure of what appears to be the major protein constituent of the bacterial nucleoid or the development of methods to titrate the extent of DNA supercoiling within the bacterial cell.

Bacterial Pathogenesis

Like eukaryotic chromosomes, bacterial chromosomes are organized into a high erorder structure called bacterial chromatin or the nucleoid. This structure facilitates the compaction and packaging of DNA into a cell that is only a ...

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Author: Brenda A. Wilson

Publisher: John Wiley & Sons

ISBN: 9781555819415

Category: Medical

Page: 683

View: 487

This highly anticipated update of the acclaimed textbook draws on the latest research to give students the knowledge and tools to explore the mechanisms by which bacterial pathogens cause infections in humans and animals. Written in an approachable and engaging style, the book uses illustrative examples and thought-provoking exercises to inspire students with the potential excitement and fun of scientific discovery. Completely revised and updated, and for the first time in stunning full-color, Bacterial Pathogenesis: A Molecular Approach, Fourth Edition, builds on the core principles and foundations of its predecessors while expanding into new concepts, key findings, and cutting-edge research, including new developments in the areas of the microbiome and CRISPR as well as the growing challenges of antimicrobial resistance. All-new detailed illustrations help students clearly understand important concepts and mechanisms of the complex interplay between bacterial pathogens and their hosts. Study questions at the end of each chapter challenge students to delve more deeply into the topics covered, and hone their skills in reading, interpreting, and analyzing data, as well as devising their own experiments. A detailed glossary defines and expands on key terms highlighted throughout the book. Written for advanced undergraduate, graduate, and professional students in microbiology, bacteriology, and pathogenesis, this text is a must-have for anyone looking for a greater understanding of virulence mechanisms across the breadth of bacterial pathogens.

Bacterial Chromatin

This book, featuring the latest research by leading experts, describes the advanced methods being applied to the problem and shows how their work is contributing to our growing understanding of the ways that bacterial DNA storage, ...

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Author: Remus Thei Dame

Publisher:

ISBN: 9048134781

Category: SCIENCE

Page: 460

View: 375

Bacterial Chromatin

This volume brings together a wide range of methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale.

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Author: Remus T. Dame

Publisher: Humana

ISBN: 1493993623

Category: Science

Page: 419

View: 224

This volume brings together a wide range of methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale. Chapters detail experimental protocols of in vivo and in vitro approaches, approaches to genome structure modeling, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

Molecular Biology

Variations in chromatin structure also exist in bacteria and archaea. DNA molecules in most bacterial species that have been studied to date have circular structures like those of the DNA molecules in Escherichia coli.

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Author: Burton E. Tropp

Publisher: Jones & Bartlett Publishers

ISBN: 9780763786632

Category: Science

Page: 1097

View: 657

"Molecular Biology: Genes to Proteins is a guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. Written for the undergraduate and first year graduate students within molecular biology or molecular genetics, the text has been updated with the latest data in the field. It incorporates a biochemical approach as well as a discovery approach that provides historical and experimental information within the context of the narrative."--Publisher.

Library of Congress Subject Headings

Bacteria , Denitrifying UF Bacteria , Nitrate - reducing Nitrate - reducing bacteria BT Bacteria RT ... synthesis BT Chemical inhibitors Bacterial chromatin [ QR76.5 ) BT Chromatin Bacterial chromosomes BT Chromosomes Bacterial cultures ...

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Author: Library of Congress

Publisher:

ISBN: UCBK:C081886584

Category: Subject headings, Library of Congress

Page:

View: 962

A E

... Bacterial BT Bacteria Cell membranes NT Endotoxins L - form bacteria Peptidoglycans Staphylococcal protein A -Synthesis - Inhibitors UF Inhibitors of bacterial cell wall synthesis BT Chemical inhibitors Bacterial chromatin ( QR76.5 ...

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Author: Library of Congress. Office for Subject Cataloging Policy

Publisher:

ISBN: SRLF:E0000738492

Category: Subject headings, Library of Congress

Page: 1548

View: 684

Library of Congress Subject Headings

... cell wall synthesis BT Chemical inhibitors Bacterial chromatin IQR76.5 ) BT Chromatin Bacterial chromosomes BT Chromosomes Bacterial cultures USE Bacteriology - Cultures and culture media Bacterial diseases ( May Subd Geog ) QR201.

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Author: Library of Congress. Cataloging Policy and Support Office

Publisher:

ISBN: UOM:39015048651866

Category: Subject headings, Library of Congress

Page:

View: 732

Bacterial Growth and Lysis

Metabolism and Structure of the Bacterial Sacculus M.A. de Pedro, J.V. Höltje, Wolfgang Löffelhardt. daughter cells are the same in both cell types. ... Gualerzi, C.O. and Pon, C.L. (1986) "Bacterial Chromatin". Springer Verlag, Berlin.

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Author: M.A. de Pedro

Publisher: Springer Science & Business Media

ISBN: 9781475793598

Category: Science

Page: 474

View: 499

This volume is based on a FEMS Symposium entitled "Bacterial Growth and Lysis: Metabolism and Structure of the Bacterial Sacculus" held at the Monastery of Lluc (Mallorca, Spain) on 5-10 April, 1992. The goals of the symposium were to assess the present state of knowledge on the structure and physiology of the bacterial murein sacculus, and to develop new hypotheses and strategies to promote further development of the field. Consequently, the contributions compiled in this volume include broadly different approaches, from the introduction of new analytical methods to the presentation of provocative models for cell wall growth and division. Structural, biochemical, and genetic aspects are widely covered with special emphasis on the enzymology and regulation of murein hydrolases (autolysins). Comprehensive reviews on bacterial S layers and yeast cell walls are included to stimulate conceptual cross-feeding with these closely related topics. We believe that this book will provide the reader with a useful and up-to-date review of the topic. We would feel deeply rewarded by any positive influence this book may have on the future progress of the field, whereby all the scientific credit for it should be given to the authors of the excellent contributions presented.