Molecular Biology in Cellular Pathology

This book describes the latest molecular techniques available for the analysis of diseases. In particular it includes new techniques using fluorescent dyes, DNA microarrays, protein chemistry, and mass spectrometry.

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Author: John Crocker

Publisher: John Wiley & Sons

ISBN: 0470844752

Category: Science

Page: 400

View: 172

The latest edition of this highly successful text, covers the major advances in the methods used in cellular and molecular pathology. In recent years, knowledge of the molecular organization of the cell has led to the development of powerful new techniques that bring greater accuracy and objectives to the diagnosis, prognosis and management of many diseases and to the study of pathological states. This book describes the latest molecular techniques available for the analysis of diseases. In particular it includes new techniques using fluorescent dyes, DNA microarrays, protein chemistry, and mass spectrometry. It also incorporates information from the Human Genome Project, and the new disciplines of genomics and proteomics, where relevant to pathology. Color plates are a new feature of this edition, illustrating the advances in fluorescence labeling of cells.

Essential Concepts in Molecular Pathology

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters.

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Author: William B. Coleman

Publisher: Academic Press

ISBN: 008092218X

Category: Science

Page: 462

View: 424

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine Each chapter ends with Key Summary Points and Suggested Readings

Molecular Pathology

The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular ...

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Author: William B. Coleman

Publisher: Academic Press

ISBN: 9780128027875

Category: Medical

Page: 802

View: 511

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Histology and Cell Biology An Introduction to Pathology E Book

This award-winning text presents key concepts in an understandable, easy-to-understand manner, with full-color illustrations, diagrams, photomicrographs, and pathology photos fully integrated on every page.

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Author: Abraham L Kierszenbaum

Publisher: Elsevier Health Sciences

ISBN: 9780323683784

Category: Medical

Page: 824

View: 856

Linking basic science to clinical application throughout, Histology and Cell Biology: An Introduction to Pathology, 5th Edition, helps students build a stronger clinical knowledge base in the challenging area of pathologic abnormalities. This award-winning text presents key concepts in an understandable, easy-to-understand manner, with full-color illustrations, diagrams, photomicrographs, and pathology photos fully integrated on every page. Student-friendly features such as highlighted clinical terms, Clinical Conditions boxes, Essential Concepts boxes, concept mapping animations, and more help readers quickly grasp complex information. Features new content on cancer immunotherapy, satellite cells and muscle repair, vasculogenesis and angiogenesis in relation to cancer treatment, and mitochondria replacement therapies. Presents new material on ciliogenesis, microtubule assembly and disassembly, chromatin structure and condensation, and X chromosome inactivation, which directly impact therapy for ciliopathies, infertility, cancer, and Alzheimer’s disease. Provides thoroughly updated information on gestational trophoblastic diseases, molecular aspects of breast cancer, and basic immunology, including new illustrations on the structure of the T-cell receptor, CD4+ cells subtypes and functions, and the structure of the human spleen. Uses a new, light green background throughout the text to identify essential concepts of histology – a feature requested by both students and instructors to quickly locate which concepts are most important for beginning learners or when time is limited. These essential concepts are followed by more detailed information on cell biology and pathology. Contains new Primers in most chapters that provide a practical, self-contained integration of histology, cell biology, and pathology – perfect for clarifying the relationship between basic and clinical sciences. Identifies clinical terms throughout the text and lists all clinical boxes in the table of contents for quick reference. Helps students understand the links between chapter concepts with concept mapping animations on Student ConsultTM – an outstanding supplement to in-class instruction.

Molecular Biology of the Arterial Wall

The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the ...

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Author: Gotthard Schettler

Publisher: Springer

ISBN: 3540178996

Category: Science

Page: 170

View: 191

The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.

Molecular Biology and Pathology of Paediatric Cancer

Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of ...

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Author: Catherine J. Cullinane

Publisher: OUP Oxford

ISBN: 9780191587238

Category: Medical

Page: 360

View: 198

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focussed on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behaviour of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. A international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is a broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Basic Concepts of Molecular Pathology

Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the ...

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Author: Philip T. Cagle

Publisher: Springer Science & Business Media

ISBN: 0387896260

Category: Medical

Page: 190

View: 749

Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Molecular Biology and Pathology

This is the first handbook to provide an all-in-one guide to establishing molecular biology protocols with requisite quality control.

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Author: Daniel H. Farkas

Publisher: Academic Press

ISBN: 9780323137805

Category: Science

Page: 326

View: 347

This is the first handbook to provide an all-in-one guide to establishing molecular biology protocols with requisite quality control. Molecular Biology and Pathology will help professionals sift through the incredible wealth of information available on molecular biology, specifically as it relates to the clinical arena of molecular pathology. This handbook provides excellent training information, and the concern of safety is discussed extensively. The handbook can serve as a primer and reference for those interested in the technical topics described, including the brief discussion of DNA banking. Quality Control (QC) suggestions are also presented.

Principles of Molecular Pathology

Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

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Author: Anthony Killeen

Publisher: Springer Science & Business Media

ISBN: 9781592594313

Category: Medical

Page: 333

View: 354

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

Oxford Textbook of Pathology

This multi-authored work provides a comprehensive account of both general and systemic pathology in the modern context.

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Author: James O'Donnell McGee

Publisher:

ISBN: OCLC:954504659

Category:

Page: 25

View: 352